Jeffrey R Infante Selected Research

GDC-0425

5/2017

Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors.

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Jeffrey R Infante Research Topics

Disease

80	Neoplasms (Cancer) 10/2021 - 01/2007
21	Melanoma (Melanoma, Malignant) 11/2020 - 09/2010
14	Neutropenia 10/2021 - 10/2011
12	Fatigue 01/2020 - 10/2012
12	Thrombocytopenia (Thrombopenia) 11/2019 - 01/2010
10	Nausea 01/2020 - 01/2010
9	Disease Progression 10/2020 - 07/2013
8	Colorectal Neoplasms (Colorectal Cancer) 02/2017 - 07/2010
7	Diarrhea 01/2020 - 01/2010
7	Renal Cell Carcinoma (Grawitz Tumor) 11/2019 - 08/2011
7	Pancreatic Neoplasms (Pancreatic Cancer) 02/2015 - 02/2008
6	Adenocarcinoma 01/2021 - 01/2007
6	Neoplasm Metastasis (Metastasis) 10/2020 - 10/2012
6	Vomiting 01/2020 - 01/2010
5	Carcinoma (Carcinomatosis) 10/2020 - 02/2008
4	Multiple Myeloma 01/2022 - 01/2013
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020 - 10/2012
4	Hypoxia (Hypoxemia) 01/2018 - 05/2011
4	Mucositis 10/2017 - 01/2010
4	Exanthema (Rash) 02/2017 - 01/2010
4	Febrile Neutropenia 08/2013 - 01/2010
3	Anemia 10/2021 - 10/2012
3	Hematologic Neoplasms (Hematological Malignancy) 06/2015 - 09/2012
2	Uveal melanoma 11/2020 - 01/2020
2	Renal Insufficiency (Renal Failure) 10/2020 - 04/2013
2	Ovarian Neoplasms (Ovarian Cancer) 01/2020 - 03/2016
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2020 - 01/2013
2	Edema (Dropsy) 01/2018 - 12/2013
2	Asthenia 01/2018 - 07/2017
2	Fever (Fevers) 05/2017 - 01/2017
2	Stomatitis 02/2017 - 08/2014
2	Lymphoma (Lymphomas) 12/2016 - 06/2015
2	Breast Neoplasms (Breast Cancer) 04/2016 - 02/2009
2	Lung Neoplasms (Lung Cancer) 03/2016 - 11/2014
2	Pain (Aches) 12/2015 - 09/2015
2	Sarcoma (Soft Tissue Sarcoma) 08/2014 - 02/2013
2	Hypersensitivity (Allergy) 10/2012 - 07/2010

Drug/Important Bio-Agent (IBA)

11	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2019 - 08/2012
10	dabrafenibIBA 03/2016 - 05/2012
9	Gemcitabine FDA Link 05/2017 - 01/2011
8	Pharmaceutical PreparationsIBA 01/2020 - 09/2012
8	trametinibIBA 01/2017 - 08/2012
7	Proteins (Proteins, Gene)FDA Link 12/2020 - 01/2007
5	avelumabIBA 10/2020 - 07/2017
5	Docetaxel (Taxotere)FDA Link 01/2017 - 02/2009
5	Carboplatin (JM8)FDA LinkGeneric 12/2015 - 08/2012
5	Bevacizumab (Avastin)FDA Link 01/2013 - 07/2010
4	Immunoglobulin G (IgG)IBA 12/2020 - 07/2017
4	Biomarkers (Surrogate Marker)IBA 11/2020 - 02/2011
4	PlatinumIBA 10/2020 - 07/2017
4	Immunoconjugates (Immunoconjugate)IBA 01/2020 - 12/2014
4	B7-H1 AntigenIBA 01/2018 - 11/2014
4	AZD 6244IBA 10/2017 - 02/2013
4	Erlotinib Hydrochloride (CP 358,774)FDA Link 10/2017 - 02/2013
4	Pemetrexed (MTA)FDA Link 01/2017 - 01/2010
4	Irinotecan (Camptosar)FDA LinkGeneric 01/2015 - 11/2012
4	Paclitaxel (Taxol)FDA LinkGeneric 12/2013 - 01/2010
4	pazopanib FDA Link 08/2013 - 01/2010
3	pegilodecakinIBA 01/2021 - 11/2018
3	LigandsIBA 10/2020 - 11/2014
3	Immune Checkpoint InhibitorsIBA 01/2019 - 11/2014
3	Tyrosine Kinase InhibitorsIBA 01/2018 - 08/2013
3	temsirolimus FDA Link 10/2017 - 02/2013
3	Dacarbazine (DIC)FDA LinkGeneric 01/2017 - 02/2013
3	Proteasome InhibitorsIBA 04/2016 - 01/2013
3	Capecitabine (Xeloda)FDA Link 04/2015 - 02/2014
3	Everolimus FDA Link 02/2015 - 09/2010
3	Monoclonal AntibodiesIBA 11/2014 - 04/2013
3	Angiogenesis InhibitorsIBA 08/2013 - 08/2011
3	Aurora Kinase AIBA 09/2012 - 02/2011
3	PanobinostatIBA 09/2012 - 03/2011
2	AntigensIBA 01/2022 - 11/2020
2	CytokinesIBA 11/2020 - 10/2014
2	AntibodiesIBA 10/2020 - 02/2008
2	NivolumabIBA 11/2019 - 12/2017
2	Glycoproteins (Glycoprotein)IBA 01/2019 - 04/2013
2	VemurafenibIBA 01/2019 - 06/2015
2	atezolizumabIBA 01/2019 - 03/2016
2	Interleukin-10 (Interleukin 10)IBA 11/2018 - 10/2016
2	PEGPH20IBA 01/2018 - 01/2014
2	Hyaluronic Acid (Hyaluronan)IBA 01/2018 - 01/2014
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2017 - 04/2016
2	trifluridine tipiracil drug combinationIBA 02/2016 - 11/2015
2	EnzymesIBA 12/2015 - 08/2013
2	TOR Serine-Threonine KinasesIBA 10/2015 - 09/2010
2	Focal Adhesion Protein-Tyrosine KinasesIBA 10/2015 - 05/2012
2	NitrogenIBA 09/2015 - 04/2013
2	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 04/2015 - 02/2015
2	ProdrugsIBA 04/2015 - 05/2011
2	Proto-Oncogene Proteins B-rafIBA 09/2013 - 09/2013
2	Transaminases (Aminotransferases)IBA 06/2013 - 01/2010
2	Midazolam (Versed)FDA LinkGeneric 01/2013 - 05/2012
2	MLN8054IBA 04/2011 - 02/2011
1	B-Cell Maturation AntigenIBA 01/2022

Therapy/Procedure

20	Therapeutics 10/2020 - 09/2010
12	Drug Therapy (Chemotherapy) 01/2019 - 09/2010
3	Immunotherapy 01/2022 - 09/2010
2	Intravenous Infusions 01/2020 - 01/2018
2	Pancreaticoduodenectomy 10/2007 - 01/2007
1	Castration 01/2022